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Bypassing the proline/thiazoline requirement of the macrocyclase PatG

Biocatalysis is a fast developing field in which an enzyme's natural capabilities are harnessed or engineered for synthetic chemistry. The enzyme PatG is an extremely promiscuous macrocyclase enzyme tolerating both non-natural amino acids and non-amino acids within the substrate. It does, howev...

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Detalles Bibliográficos
Autores principales: Oueis, E., Stevenson, H., Jaspars, M., Westwood, N. J., Naismith, J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708355/
https://www.ncbi.nlm.nih.gov/pubmed/29090689
http://dx.doi.org/10.1039/c7cc06550g