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From [(11)C]CO(2) to [(11)C]amides: a rapid one-pot synthesis via the Mitsunobu reaction
A novel amide synthesis methodology is described using amines, CO(2) and Grignard reagents and Mitsunobu reagents. The method was applied to carbon-11 radiochemistry to label amides using cyclotron-produced [(11)C]CO(2). The synthetic utility of the one-pot labelling methodology was demonstrated by...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708528/ https://www.ncbi.nlm.nih.gov/pubmed/28447672 http://dx.doi.org/10.1039/c7cc01407d |