Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA

Little is known about association between ABO blood groups and tumor markers in gastric cancer (GC) patients. The aim of the present study was to assess the prognostic value of ABO blood groups in GC patients with different levels of preoperative serum carcinoembryonic antigen (CEA). From September...

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Autores principales: Xiao, Shuao, Feng, Fan, Sun, Li, Cai, Lei, Liu, Zhen, Liu, Shushang, Fan, Daiming, Zhang, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708924/
https://www.ncbi.nlm.nih.gov/pubmed/29381925
http://dx.doi.org/10.1097/MD.0000000000008496
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author Xiao, Shuao
Feng, Fan
Sun, Li
Cai, Lei
Liu, Zhen
Liu, Shushang
Fan, Daiming
Zhang, Hongwei
author_facet Xiao, Shuao
Feng, Fan
Sun, Li
Cai, Lei
Liu, Zhen
Liu, Shushang
Fan, Daiming
Zhang, Hongwei
author_sort Xiao, Shuao
collection PubMed
description Little is known about association between ABO blood groups and tumor markers in gastric cancer (GC) patients. The aim of the present study was to assess the prognostic value of ABO blood groups in GC patients with different levels of preoperative serum carcinoembryonic antigen (CEA). From September 2008 to April 2015, a total of 3234 GC patients who received radical gastrectomy were retrospectively analyzed. The clinicopathological characteristics including ABO blood groups and preoperative CEA were recorded. The prognostic value of ABO blood groups within different levels of serum CEA was analyzed. Overall, the ratio of male to female patients was 3.5:1; the median age was 57.4 years (range 20–87). The median overall survival (OS) for GC patients with blood type A, B, AB, and O were 52.6, 52.8, 53.8, and 53.6 months, respectively. There was no significant difference for the survival of patients among the 4 groups (P = .736). Also, no significant difference was found among the OS of the 4 blood types with negative (P = .875) and positive (P = .131) preoperative serum CEA. Further, we found that the OS of patients with positive preoperative serum CEA and blood type AB was significantly higher than that with blood type non-AB (P = .026). For patients with positive preoperative serum CEA, multivariate analysis showed that ABO blood groups were an independent prognostic factor. Blood type AB was a favorable prognostic factor for GC patients with positive preoperative serum CEA.
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spelling pubmed-57089242017-12-07 Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA Xiao, Shuao Feng, Fan Sun, Li Cai, Lei Liu, Zhen Liu, Shushang Fan, Daiming Zhang, Hongwei Medicine (Baltimore) 5700 Little is known about association between ABO blood groups and tumor markers in gastric cancer (GC) patients. The aim of the present study was to assess the prognostic value of ABO blood groups in GC patients with different levels of preoperative serum carcinoembryonic antigen (CEA). From September 2008 to April 2015, a total of 3234 GC patients who received radical gastrectomy were retrospectively analyzed. The clinicopathological characteristics including ABO blood groups and preoperative CEA were recorded. The prognostic value of ABO blood groups within different levels of serum CEA was analyzed. Overall, the ratio of male to female patients was 3.5:1; the median age was 57.4 years (range 20–87). The median overall survival (OS) for GC patients with blood type A, B, AB, and O were 52.6, 52.8, 53.8, and 53.6 months, respectively. There was no significant difference for the survival of patients among the 4 groups (P = .736). Also, no significant difference was found among the OS of the 4 blood types with negative (P = .875) and positive (P = .131) preoperative serum CEA. Further, we found that the OS of patients with positive preoperative serum CEA and blood type AB was significantly higher than that with blood type non-AB (P = .026). For patients with positive preoperative serum CEA, multivariate analysis showed that ABO blood groups were an independent prognostic factor. Blood type AB was a favorable prognostic factor for GC patients with positive preoperative serum CEA. Wolters Kluwer Health 2017-11-27 /pmc/articles/PMC5708924/ /pubmed/29381925 http://dx.doi.org/10.1097/MD.0000000000008496 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3 This material is licensed under the terms of the Open Government Licence except where otherwise stated. To view this licence, visit http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London, TW9 4DU, or email: psi@nationalarchives.gsi.gov.uk (mailto:psi@nationalarchives.gsi.gov.uk) . http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3
spellingShingle 5700
Xiao, Shuao
Feng, Fan
Sun, Li
Cai, Lei
Liu, Zhen
Liu, Shushang
Fan, Daiming
Zhang, Hongwei
Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA
title Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA
title_full Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA
title_fullStr Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA
title_full_unstemmed Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA
title_short Blood type AB predicts promising prognosis in gastric cancer patients with positive preoperative serum CEA
title_sort blood type ab predicts promising prognosis in gastric cancer patients with positive preoperative serum cea
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708924/
https://www.ncbi.nlm.nih.gov/pubmed/29381925
http://dx.doi.org/10.1097/MD.0000000000008496
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