Deregulation of kinase signaling and lymphoid development in EBF1-PDGFRB ALL leukemogenesis

The chimeric fusion oncogene EBF1-PDGFRB is a recurrent lesion observed in Ph-like B-ALL and is associated with particularly poor prognosis. While it is understood that this fusion activates tyrosine kinase signaling, the mechanisms of transformation and importance of perturbation of EBF1 activity r...

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Detalles Bibliográficos
Autores principales: Welsh, Seth J., Churchman, Michelle L., Togni, Marco, Mullighan, Charles G., Hagman, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709252/
https://www.ncbi.nlm.nih.gov/pubmed/28555080
http://dx.doi.org/10.1038/leu.2017.166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709252/
https://www.ncbi.nlm.nih.gov/pubmed/28555080
http://dx.doi.org/10.1038/leu.2017.166

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