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Deregulation of kinase signaling and lymphoid development in EBF1-PDGFRB ALL leukemogenesis
The chimeric fusion oncogene EBF1-PDGFRB is a recurrent lesion observed in Ph-like B-ALL and is associated with particularly poor prognosis. While it is understood that this fusion activates tyrosine kinase signaling, the mechanisms of transformation and importance of perturbation of EBF1 activity r...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709252/ https://www.ncbi.nlm.nih.gov/pubmed/28555080 http://dx.doi.org/10.1038/leu.2017.166 |