Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus

We report here that in rat and human neuroprogenitor cells as well as rat embryonic cortical neurons Zika virus (ZIKV) infection leads to ribosomal stress that is characterized by structural disruption of the nucleolus. The anti-nucleolar effects were most pronounced in postmitotic neurons. Moreover...

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Detalles Bibliográficos
Autores principales: Slomnicki, Lukasz P., Chung, Dong-Hoon, Parker, Austin, Hermann, Taylor, Boyd, Nolan L., Hetman, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709411/
https://www.ncbi.nlm.nih.gov/pubmed/29192272
http://dx.doi.org/10.1038/s41598-017-16952-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709411/
https://www.ncbi.nlm.nih.gov/pubmed/29192272
http://dx.doi.org/10.1038/s41598-017-16952-8

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