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Fine control of metal concentrations is necessary for cells to discern zinc from cobalt
Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but metal binding is not specific in vitro. Here we show that tight regulation of buffered intracellular metal concentrations is a prerequisite for metal specificity of Zur, ZntR, RcnR and F...
Autores principales: | Osman, Deenah, Foster, Andrew W., Chen, Junjun, Svedaite, Kotryna, Steed, Jonathan W., Lurie-Luke, Elena, Huggins, Thomas G., Robinson, Nigel J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709419/ https://www.ncbi.nlm.nih.gov/pubmed/29192165 http://dx.doi.org/10.1038/s41467-017-02085-z |
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