Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories

Prion-like misfolding of superoxide dismutase 1 (SOD1) is associated with the disease ALS, but the mechanism of misfolding remains unclear, partly because misfolding is difficult to observe directly. Here we study the most misfolding-prone form of SOD1, reduced un-metallated monomers, using optical...

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Detalles Bibliográficos
Autores principales: Sen Mojumdar, Supratik, N. Scholl, Zackary, Dee, Derek R., Rouleau, Logan, Anand, Uttam, Garen, Craig, Woodside, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709426/
https://www.ncbi.nlm.nih.gov/pubmed/29192167
http://dx.doi.org/10.1038/s41467-017-01996-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709426/
https://www.ncbi.nlm.nih.gov/pubmed/29192167
http://dx.doi.org/10.1038/s41467-017-01996-1

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