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Up-regulation of Interleukin-21 Contributes to Liver Pathology of Schistosomiasis by Driving GC Immune Responses and Activating HSCs in Mice
The pathology of schistosome egg-induced liver granuloma, fibrosis and eventually liver scarring is complicated. CD4(+) helper T (Th) cells play critical roles in both host humoral immunity and cellular immunity against parasitic infection and immunopathology in schistosomiasis. Follicular helper T...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709429/ https://www.ncbi.nlm.nih.gov/pubmed/29192177 http://dx.doi.org/10.1038/s41598-017-16783-7 |