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Developmental changes in GABA(A) tonic inhibition are compromised by multiple mechanisms in preadolescent dentate gyrus granule cells

The sustained tonic currents (I(tonic)) generated by γ-aminobutyric acid A receptors (GABA(A)Rs) are implicated in diverse age-dependent brain functions. While various mechanisms regulating I(tonic) in the hippocampus are known, their combined role in I(tonic) regulation is not well understood in di...

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Detalles Bibliográficos
Autores principales: Pandit, Sudip, Lee, Gyu Seung, Park, Jin Bong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709487/
https://www.ncbi.nlm.nih.gov/pubmed/29200913
http://dx.doi.org/10.4196/kjpp.2017.21.6.695