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Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1

Calcium phosphate-based mineralo-organic particles form spontaneously in the body and may represent precursors of ectopic calcification. We have shown earlier that these particles induce activation of caspase-1 and secretion of IL-1β by macrophages. However, whether the particles may produce other e...

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Detalles Bibliográficos
Autores principales: Peng, Hsin-Hsin, Liu, Yu-Ju, Ojcius, David M., Lee, Chiou-Mei, Chen, Ren-Hao, Huang, Pei-Rong, Martel, Jan, Young, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709501/
https://www.ncbi.nlm.nih.gov/pubmed/29192209
http://dx.doi.org/10.1038/s41598-017-16778-4