Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways

Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by these mutations, whether dependent or not on the oncometabolite D‐2‐hydroxyglut...

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Detalles Bibliográficos
Autores principales: Fack, Fred, Tardito, Saverio, Hochart, Guillaume, Oudin, Anais, Zheng, Liang, Fritah, Sabrina, Golebiewska, Anna, Nazarov, Petr V, Bernard, Amandine, Hau, Ann‐Christin, Keunen, Olivier, Leenders, William, Lund‐Johansen, Morten, Stauber, Jonathan, Gottlieb, Eyal, Bjerkvig, Rolf, Niclou, Simone P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709746/
https://www.ncbi.nlm.nih.gov/pubmed/29054837
http://dx.doi.org/10.15252/emmm.201707729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709746/
https://www.ncbi.nlm.nih.gov/pubmed/29054837
http://dx.doi.org/10.15252/emmm.201707729

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