Multistep Conformation Selection in Amyloid Assembly

[Image: see text] Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facia...

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Detalles Bibliográficos
Autores principales: Hsieh, Ming-Chien, Liang, Chen, Mehta, Anil K., Lynn, David G., Grover, Martha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709775/
https://www.ncbi.nlm.nih.gov/pubmed/29111722
http://dx.doi.org/10.1021/jacs.7b09362
Descripción
Sumario:[Image: see text] Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facial complementarity is a critical determinant for amyloid nucleation and structural selection.

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