Multistep Conformation Selection in Amyloid Assembly

[Image: see text] Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facia...

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Autores principales: Hsieh, Ming-Chien, Liang, Chen, Mehta, Anil K., Lynn, David G., Grover, Martha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709775/
https://www.ncbi.nlm.nih.gov/pubmed/29111722
http://dx.doi.org/10.1021/jacs.7b09362
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author Hsieh, Ming-Chien
Liang, Chen
Mehta, Anil K.
Lynn, David G.
Grover, Martha A.
author_facet Hsieh, Ming-Chien
Liang, Chen
Mehta, Anil K.
Lynn, David G.
Grover, Martha A.
author_sort Hsieh, Ming-Chien
collection PubMed
description [Image: see text] Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facial complementarity is a critical determinant for amyloid nucleation and structural selection.
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spelling pubmed-57097752017-12-04 Multistep Conformation Selection in Amyloid Assembly Hsieh, Ming-Chien Liang, Chen Mehta, Anil K. Lynn, David G. Grover, Martha A. J Am Chem Soc [Image: see text] Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facial complementarity is a critical determinant for amyloid nucleation and structural selection. American Chemical Society 2017-11-07 2017-11-29 /pmc/articles/PMC5709775/ /pubmed/29111722 http://dx.doi.org/10.1021/jacs.7b09362 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Hsieh, Ming-Chien
Liang, Chen
Mehta, Anil K.
Lynn, David G.
Grover, Martha A.
Multistep Conformation Selection in Amyloid Assembly
title Multistep Conformation Selection in Amyloid Assembly
title_full Multistep Conformation Selection in Amyloid Assembly
title_fullStr Multistep Conformation Selection in Amyloid Assembly
title_full_unstemmed Multistep Conformation Selection in Amyloid Assembly
title_short Multistep Conformation Selection in Amyloid Assembly
title_sort multistep conformation selection in amyloid assembly
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709775/
https://www.ncbi.nlm.nih.gov/pubmed/29111722
http://dx.doi.org/10.1021/jacs.7b09362
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