Performance comparison of first-order conditional estimation with interaction and Bayesian estimation methods for estimating the population parameters and its distribution from data sets with a low number of subjects

BACKGROUND: Exploratory preclinical, as well as clinical trials, may involve a small number of patients, making it difficult to calculate and analyze the pharmacokinetic (PK) parameters, especially if the PK parameters show very high inter-individual variability (IIV). In this study, the performance...

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Detalles Bibliográficos
Autores principales: Pradhan, Sudeep, Song, Byungjeong, Lee, Jaeyeon, Chae, Jung-woo, Kim, Kyung Im, Back, Hyun-moon, Han, Nayoung, Kwon, Kwang-il, Yun, Hwi-yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709938/
https://www.ncbi.nlm.nih.gov/pubmed/29191177
http://dx.doi.org/10.1186/s12874-017-0427-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709938/
https://www.ncbi.nlm.nih.gov/pubmed/29191177
http://dx.doi.org/10.1186/s12874-017-0427-0

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