CDK1 promotes nascent DNA synthesis and induces resistance of cancer cells to DNA-damaging therapeutic agents

Cyclin dependent kinase 1 (CDK1) is essential for cell viability and plays a vital role in many biological events including cell cycle control, DNA damage repair, and checkpoint activation. Here, we identify an unanticipated role for CDK1 in promoting nascent DNA synthesis during S-phase. We report...

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Detalles Bibliográficos
Autores principales: Liao, Hongwei, Ji, Fang, Geng, Xinwei, Xing, Meichun, Li, Wen, Chen, Zhihua, Shen, Huahao, Ying, Songmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710876/
https://www.ncbi.nlm.nih.gov/pubmed/29207595
http://dx.doi.org/10.18632/oncotarget.21730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710876/
https://www.ncbi.nlm.nih.gov/pubmed/29207595
http://dx.doi.org/10.18632/oncotarget.21730

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