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Combination therapy with an OX40L fusion protein and a vaccine targeting the transcription factor twist inhibits metastasis in a murine model of breast cancer
OX40 is a costimulatory receptor that potentiates proliferation, survival, memory formation, and effector function of CD4(+) and CD8(+) T-cells, while overcoming the suppressive activity of regulatory T-cells (Tregs). Here, we explored the combination of an OX40L fusion protein (OX40L-FP) with a pox...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710887/ https://www.ncbi.nlm.nih.gov/pubmed/29207606 http://dx.doi.org/10.18632/oncotarget.19967 |