PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose

Cancer metabolism has emerged as an increasingly attractive target for interfering with tumor growth. Small molecule activators of pyruvate kinase isozyme M2 (PKM2) suppress tumor formation but have an unknown effect on established tumors. We demonstrate that TEPP-46, a PKM2 activator, results in in...

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Detalles Bibliográficos
Autores principales: Tee, Sui Seng, Park, Jae Mo, Hurd, Ralph E., Brimacombe, Kyle R., Boxer, Matthew B., Massoud, Tarik F., Rutt, Brian K., Spielman, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710897/
https://www.ncbi.nlm.nih.gov/pubmed/29207616
http://dx.doi.org/10.18632/oncotarget.19630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710897/
https://www.ncbi.nlm.nih.gov/pubmed/29207616
http://dx.doi.org/10.18632/oncotarget.19630

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