Shp2 regulates migratory behavior and response to EGFR-TKIs through ERK1/2 pathway activation in non-small cell lung cancer cells

In the clinical treatment of lung cancer, therapy failure is mainly caused by cancer metastasis and drug resistance. Here, we investigated whether the tyrosine phosphatase Shp2 is involved in the development of metastasis and drug resistance in non-small cell lung cancer (NSCLC). Shp2 was overexpres...

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Detalles Bibliográficos
Autores principales: Sun, Yu-Jing, Zhuo, Zhong-Ling, Xian, Hai-Peng, Chen, Ke-Zhong, Yang, Fan, Zhao, Xiao-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710910/
https://www.ncbi.nlm.nih.gov/pubmed/29207630
http://dx.doi.org/10.18632/oncotarget.20249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710910/
https://www.ncbi.nlm.nih.gov/pubmed/29207630
http://dx.doi.org/10.18632/oncotarget.20249

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