Accurate quantification of 5-Methylcytosine, 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine in genomic DNA from breast cancer by chemical derivatization coupled with ultra performance liquid chromatography- electrospray quadrupole time of flight mass spectrometry analysis

The DNA demethylation pathway has been discovered to play a significant role in DNA epigenetics. This pathway removes the methyl group from cytosine, which is involved in the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) by ten-eleven translocation (TET) proteins. Then, 5-hmC can...

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Detalles Bibliográficos
Autores principales: Guo, Mengzhe, Li, Xiao, Zhang, Liyan, Liu, Dantong, Du, Wencheng, Yin, Dengyang, Lyu, Nan, Zhao, Guangyu, Guo, Cheng, Tang, Daoquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710920/
https://www.ncbi.nlm.nih.gov/pubmed/29207640
http://dx.doi.org/10.18632/oncotarget.20093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710920/
https://www.ncbi.nlm.nih.gov/pubmed/29207640
http://dx.doi.org/10.18632/oncotarget.20093

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