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Discovery of novel frizzled-7 inhibitors by targeting the receptor’s transmembrane domain

Frizzled (Fzd) proteins are seven transmembrane receptors that belong to a novel and separated family of G-protein-coupled receptors (GPCRs). The Fzd receptors can respond to Wnt proteins to activate the canonical β-catenin pathway which is important for both initiation and progression of cancers. D...

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Detalles Bibliográficos
Autores principales:	Zhang, Wei, Lu, Wenyan, Ananthan, Subramaniam, Suto, Mark J., Li, Yonghe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710937/ https://www.ncbi.nlm.nih.gov/pubmed/29207657 http://dx.doi.org/10.18632/oncotarget.20665

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