Statistical investigation of the full concentration range of fasted and fed simulated intestinal fluid on the equilibrium solubility of oral drugs

Upon oral administration the solubility of a drug in intestinal fluid is a key property influencing bioavailability. It is also recognised that simple aqueous solubility does not reflect intestinal solubility and to optimise in vitro investigations simulated intestinal media systems have been develo...

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Detalles Bibliográficos
Autores principales: Perrier, Jeremy, Zhou, Zhou, Dunn, Claire, Khadra, Ibrahim, Wilson, Clive G., Halbert, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710999/
https://www.ncbi.nlm.nih.gov/pubmed/28987539
http://dx.doi.org/10.1016/j.ejps.2017.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710999/
https://www.ncbi.nlm.nih.gov/pubmed/28987539
http://dx.doi.org/10.1016/j.ejps.2017.10.007

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