Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire

Cullin-RING ubiquitin ligases (CRLs) catalyze the ubiquitylation of substrates many of which are degraded by the 26S proteasome. Their modular architecture enables recognition of numerous substrates via exchangeable substrate receptors that competitively bind to a cullin scaffold with high affinity....

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Detalles Bibliográficos
Autores principales: Straube, Ronny, Shah, Meera, Flockerzi, Dietrich, Wolf, Dieter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711038/
https://www.ncbi.nlm.nih.gov/pubmed/29149173
http://dx.doi.org/10.1371/journal.pcbi.1005869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711038/
https://www.ncbi.nlm.nih.gov/pubmed/29149173
http://dx.doi.org/10.1371/journal.pcbi.1005869

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