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Perturbation of the T cell receptor repertoire occurs with increasing age in dogs

Immunosenescence is the gradual deterioration in immune system function associated with ageing. This decline is partly due to involution of the thymus, which leads to a reduction in the output of naive T cells into the circulating lymphocyte pool. Expansion of existing naive and memory T cell popula...

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Detalles Bibliográficos
Autores principales: Holder, Angela, Mirczuk, Samantha M., Fowkes, Robert C., Palmer, Donald B., Aspinall, Richard, Catchpole, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711257/
https://www.ncbi.nlm.nih.gov/pubmed/29103899
http://dx.doi.org/10.1016/j.dci.2017.10.020