Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) and Notch Signaling in an Experimental Rat Model

Alcohol-induced white matter (WM) degeneration is linked to cognitive-motor deficits and impairs insulin/insulin-like growth factor (IGF) and Notch networks regulating oligodendrocyte function. Ethanol downregulates Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) which drives Notch. These experiments dete...

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Detalles Bibliográficos
Autores principales: Tong, Ming, Gonzalez-Navarrete, Howard, Kirchberg, Tyler, Gotama, Billy, Yalcin, Emine B., Kay, Jared, de la Monte, Suzanne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711436/
https://www.ncbi.nlm.nih.gov/pubmed/29204305
http://dx.doi.org/10.4303/jdar/236033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711436/
https://www.ncbi.nlm.nih.gov/pubmed/29204305
http://dx.doi.org/10.4303/jdar/236033

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