Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design

Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24-/28-methylases (SMTs) that catalyze the committed step in C(28)- and C(29)...

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Detalles Bibliográficos
Autores principales: Kidane, Medhanie E., Vanderloop, Boden H., Zhou, Wenxu, Thomas, Crista D., Ramos, Emilio, Singha, Ujjal, Chaudhuri, Minu, Nes, W. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711494/
https://www.ncbi.nlm.nih.gov/pubmed/29042405
http://dx.doi.org/10.1194/jlr.M079418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711494/
https://www.ncbi.nlm.nih.gov/pubmed/29042405
http://dx.doi.org/10.1194/jlr.M079418

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