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Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design
Ergosterol biosynthesis pathways essential to pathogenic protozoa growth and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24-/28-methylases (SMTs) that catalyze the committed step in C(28)- and C(29)...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Biochemistry and Molecular Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711494/ https://www.ncbi.nlm.nih.gov/pubmed/29042405 http://dx.doi.org/10.1194/jlr.M079418 |