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Toehold-enhanced LNA probes for selective pull down and single-molecule analysis of native chromatin
The organization of DNA into chromatin is thought to regulate gene expression in eukaryotes. To study its structure in vitro, there is a need for techniques that can isolate specific chromosomal loci of natively assembled chromatin. Current purification methods often involve chemical cross-linking t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711847/ https://www.ncbi.nlm.nih.gov/pubmed/29196662 http://dx.doi.org/10.1038/s41598-017-16864-7 |