Preferential selection of Arginine at the lipid-water-interface of TRPV1 during vertebrate evolution correlates with its snorkeling behaviour and cholesterol interaction

TRPV1 is a thermo-sensitive ion channel involved in neurosensory and other physiological functions. The trans-membrane helices of TRPV1 undergo quick and complex conformational changes governed by thermodynamic parameters and membrane components leading to channel opening. However, the molecular mec...

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Detalles Bibliográficos
Autores principales: Saha, Somdatta, Ghosh, Arijit, Tiwari, Nikhil, Kumar, Ashutosh, Kumar, Abhishek, Goswami, Chandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711878/
https://www.ncbi.nlm.nih.gov/pubmed/29196683
http://dx.doi.org/10.1038/s41598-017-16780-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711878/
https://www.ncbi.nlm.nih.gov/pubmed/29196683
http://dx.doi.org/10.1038/s41598-017-16780-w

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