The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity

We have investigated whether mineralocorticoid receptor activation can participate in the profibrotic effects of leptin in cardiac myofibroblasts, as well as the potential mechanisms involved. The presence of eplerenone reduced the leptin-induced increase in protein levels of collagen I, transformin...

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Detalles Bibliográficos
Autores principales: Gutiérrez-Tenorio, Josué, Marín-Royo, Gema, Martínez-Martínez, Ernesto, Martín, Rubén, Miana, María, López-Andrés, Natalia, Jurado-López, Raquel, Gallardo, Isabel, Luaces, María, San Román, José Alberto, González-Amor, María, Salaices, Mercedes, Nieto, María Luisa, Cachofeiro, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711898/
https://www.ncbi.nlm.nih.gov/pubmed/29196758
http://dx.doi.org/10.1038/s41598-017-17103-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711898/
https://www.ncbi.nlm.nih.gov/pubmed/29196758
http://dx.doi.org/10.1038/s41598-017-17103-9

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