Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene

Deletion of Glu139 in β-tropomyosin caused by a point mutation in TPM2 gene is associated with cap myopathy characterized by high myofilament Ca(2+)-sensitivity and muscle weakness. To reveal the mechanism of these disorders at molecular level, mobility and spatial rearrangements of actin, tropomyos...

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Detalles Bibliográficos
Autores principales: Borovikov, Yurii S., Rysev, Nikita A., Karpicheva, Olga E., Sirenko, Vladimir V., Avrova, Stanislava V., Piers, Adam, Redwood, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711931/
https://www.ncbi.nlm.nih.gov/pubmed/29196649
http://dx.doi.org/10.1038/s41598-017-17076-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711931/
https://www.ncbi.nlm.nih.gov/pubmed/29196649
http://dx.doi.org/10.1038/s41598-017-17076-9

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