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Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene
Deletion of Glu139 in β-tropomyosin caused by a point mutation in TPM2 gene is associated with cap myopathy characterized by high myofilament Ca(2+)-sensitivity and muscle weakness. To reveal the mechanism of these disorders at molecular level, mobility and spatial rearrangements of actin, tropomyos...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711931/ https://www.ncbi.nlm.nih.gov/pubmed/29196649 http://dx.doi.org/10.1038/s41598-017-17076-9 |