The repeat region of cortactin is intrinsically disordered in solution

The multi-domain protein, cortactin, contains a 37-residue repeating motif that binds to actin filaments. This cortactin repeat region comprises 6½ similar copies of the motif and binds actin filaments. To better understand this region of cortactin, and its fold, we conducted extensive biophysical a...

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Detalles Bibliográficos
Autores principales: Li, Xiaofeng, Tao, Yeqing, Murphy, James W., Scherer, Alexander N., Lam, TuKiet T., Marshall, Alan G., Koleske, Anthony J., Boggon, Titus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711941/
https://www.ncbi.nlm.nih.gov/pubmed/29196701
http://dx.doi.org/10.1038/s41598-017-16959-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711941/
https://www.ncbi.nlm.nih.gov/pubmed/29196701
http://dx.doi.org/10.1038/s41598-017-16959-1

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