Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity

Rosemary extract is used in food additives and traditional medicine and has been observed to contain anti-tumor activity. In this study, rosemary extract is hypothesized to induce synthetic lethality in BRCA2 deficient cells by PARP inhibition. Chinese hamster lung V79 cells and its mutant cell line...

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Detalles Bibliográficos
Autores principales: Su, Cathy, Gius, Jeffrey P., Van Steenberg, Julia, Haskins, Alexis H., Heishima, Kazuki, Omata, Chisato, Iwayama, Masahiro, Murakami, Mami, Mori, Takashi, Maruo, Kohji, Kato, Takamitsu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711971/
https://www.ncbi.nlm.nih.gov/pubmed/29196727
http://dx.doi.org/10.1038/s41598-017-16795-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711971/
https://www.ncbi.nlm.nih.gov/pubmed/29196727
http://dx.doi.org/10.1038/s41598-017-16795-3

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