Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes

Inflammatory burden is a primary cellular event in many liver diseases, and the overall capacity of drug elimination is decreased. PXR (pregnane X receptor) and CAR (constitutive androstane receptor) are two master regulators of genes encoding drug-metabolizing enzymes and transporters. DEC1 (differ...

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Detalles Bibliográficos
Autores principales: Ning, Rui, Zhan, Yunran, He, Shuangcheng, Hu, Jinhua, Zhu, Zhu, Hu, Gang, Yan, Bingfang, Yang, Jian, Liu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712319/
https://www.ncbi.nlm.nih.gov/pubmed/29234281
http://dx.doi.org/10.3389/fphar.2017.00866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712319/
https://www.ncbi.nlm.nih.gov/pubmed/29234281
http://dx.doi.org/10.3389/fphar.2017.00866

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