Ocular surface reconstruction in limbal stem cell deficiency

The purpose of our review was to familiarize the readers with the new concepts in ocular surface diseases and reconstruction. Limbal stem cell deficiency is characterized by the progressive invasion of conjunctival epithelial cells onto the cornea, superficial vascularisation, destruction of the cor...

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Autores principales: Alina, Gheorghe, Monica, Pop, Fildis, Mrini, Ramona, Barac, Iulia, Vargau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Romanian Society of Ophthalmology 2016
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712914/
https://www.ncbi.nlm.nih.gov/pubmed/27220223
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author Alina, Gheorghe
Monica, Pop
Fildis, Mrini
Ramona, Barac
Iulia, Vargau
author_facet Alina, Gheorghe
Monica, Pop
Fildis, Mrini
Ramona, Barac
Iulia, Vargau
author_sort Alina, Gheorghe
collection PubMed
description The purpose of our review was to familiarize the readers with the new concepts in ocular surface diseases and reconstruction. Limbal stem cell deficiency is characterized by the progressive invasion of conjunctival epithelial cells onto the cornea, superficial vascularisation, destruction of the corneal basement membrane, and chronic inflammatory cell infiltration. Depending on the severity of the disease and the time passed from the primary injury amniotic membrane transplantation, keratolimbal allograft and autograft are the available treatments hoping that, in the nearest future, stem cell transplantation and tissue engineering will become the usual therapeutic choices. Abbreviations: LSCD = limbal stem cell deficiency; AMT = amniotic membrane transplant; OSR = ocular surface reconstruction; AM = amniotic membrane
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spelling pubmed-57129142017-12-14 Ocular surface reconstruction in limbal stem cell deficiency Alina, Gheorghe Monica, Pop Fildis, Mrini Ramona, Barac Iulia, Vargau Rom J Ophthalmol Reviews The purpose of our review was to familiarize the readers with the new concepts in ocular surface diseases and reconstruction. Limbal stem cell deficiency is characterized by the progressive invasion of conjunctival epithelial cells onto the cornea, superficial vascularisation, destruction of the corneal basement membrane, and chronic inflammatory cell infiltration. Depending on the severity of the disease and the time passed from the primary injury amniotic membrane transplantation, keratolimbal allograft and autograft are the available treatments hoping that, in the nearest future, stem cell transplantation and tissue engineering will become the usual therapeutic choices. Abbreviations: LSCD = limbal stem cell deficiency; AMT = amniotic membrane transplant; OSR = ocular surface reconstruction; AM = amniotic membrane Romanian Society of Ophthalmology 2016 /pmc/articles/PMC5712914/ /pubmed/27220223 Text en ©Romanian Society of Ophthalmology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Alina, Gheorghe
Monica, Pop
Fildis, Mrini
Ramona, Barac
Iulia, Vargau
Ocular surface reconstruction in limbal stem cell deficiency
title Ocular surface reconstruction in limbal stem cell deficiency
title_full Ocular surface reconstruction in limbal stem cell deficiency
title_fullStr Ocular surface reconstruction in limbal stem cell deficiency
title_full_unstemmed Ocular surface reconstruction in limbal stem cell deficiency
title_short Ocular surface reconstruction in limbal stem cell deficiency
title_sort ocular surface reconstruction in limbal stem cell deficiency
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712914/
https://www.ncbi.nlm.nih.gov/pubmed/27220223
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AT monicapop ocularsurfacereconstructioninlimbalstemcelldeficiency
AT fildismrini ocularsurfacereconstructioninlimbalstemcelldeficiency
AT ramonabarac ocularsurfacereconstructioninlimbalstemcelldeficiency
AT iuliavargau ocularsurfacereconstructioninlimbalstemcelldeficiency

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