Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation

Ras proteins, as small GTPases, mediate cell proliferation, survival and differentiation. Ras mutations have been associated with a broad spectrum of human cancers and thus targeting Ras represents a potential way forward for cancer therapy. A recently reported monobody NS1 allosterically disrupts t...

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Detalles Bibliográficos
Autores principales: Ni, Duan, Song, Kun, Zhang, Jian, Lu, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713219/
https://www.ncbi.nlm.nih.gov/pubmed/29072601
http://dx.doi.org/10.3390/ijms18112249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713219/
https://www.ncbi.nlm.nih.gov/pubmed/29072601
http://dx.doi.org/10.3390/ijms18112249

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