Real-Time Observation of the Interaction between Thioflavin T and an Amyloid Protein by Using High-Sensitivity Rheo-NMR

Amyloid fibril formation is associated with numerous neurodegenerative diseases. To elucidate the mechanism of fibril formation, the thioflavin T (ThT) fluorescence assay is widely used. ThT is a fluorescent dye that selectively binds to amyloid fibrils and exhibits fluorescence enhancement, which e...

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Detalles Bibliográficos
Autores principales: Iwakawa, Naoto, Morimoto, Daichi, Walinda, Erik, Kawata, Yasushi, Shirakawa, Masahiro, Sugase, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713241/
https://www.ncbi.nlm.nih.gov/pubmed/29143789
http://dx.doi.org/10.3390/ijms18112271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713241/
https://www.ncbi.nlm.nih.gov/pubmed/29143789
http://dx.doi.org/10.3390/ijms18112271

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