Cargando…

G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells

One of the most common characteristics of cancer cells is genomic instability. Recent research has revealed that G2/M-phase checkpoint adaptation—entering mitosis with damaged DNA—contributes to genomic changes in experimental models. When cancer cells are treated with pharmacological concentrations...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kalsbeek, Danî, Golsteyn, Roy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713313/ https://www.ncbi.nlm.nih.gov/pubmed/29113112 http://dx.doi.org/10.3390/ijms18112344

Ejemplares similares

Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division
por: He, Bin, et al.
Publicado: (2019)

Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells
por: Swift, Lucy H., et al.
Publicado: (2014)

cGAS surveillance of micronuclei links genome instability to innate immunity
por: Mackenzie, Karen J., et al.
Publicado: (2017)

A MATLAB-based program for three-dimensional quantitative analysis of micronuclei reveals that neuroinflammation induces micronuclei formation in the brain
por: Yano, Sarasa, et al.
Publicado: (2021)

Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells
por: Gomes, Ana Margarida, et al.
Publicado: (2022)

An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors
por: Orr, Bernardo, et al.
Publicado: (2021)

The frequencies of micronuclei, nucleoplasmic bridges and nuclear buds as biomarkers of genomic instability in patients with urothelial cell carcinoma
por: Podrimaj-Bytyqi, Arjeta, et al.
Publicado: (2018)

ER Stress and Micronuclei Cluster: Stress Response Contributes to Genome Chaos in Cancer
por: Heng, Eric, et al.
Publicado: (2021)

FISH in analysis of gamma ray-induced micronuclei formation in barley
por: Juchimiuk-Kwasniewska, Jolanta, et al.
Publicado: (2010)

Emergence of micronuclei as a genomic biomarker
por: Sabharwal, Robin, et al.
Publicado: (2015)

Association of CHMP4B and Autophagy with Micronuclei: Implications for Cataract Formation
por: Sagona, Antonia P., et al.
Publicado: (2014)

New models for prediction of micronuclei formation in nuclear medicine department workers
por: Terzic, Sanja, et al.
Publicado: (2015)

TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS
por: Droppelmann, Cristian A., et al.
Publicado: (2019)

Micronuclei and Genome Chaos: Changing the System Inheritance
por: Ye, Christine J., et al.
Publicado: (2019)

No threshold dose for micronuclei induction?
por: Diehl-Marshall, I, et al.
Publicado: (1981)

Paternal Cyclophosphamide Exposure Induces the Formation of Functional Micronuclei during the First Zygotic Division
por: Grenier, Lisanne, et al.
Publicado: (2011)

Micronuclei formation in liver fibrosis samples from patients infected by hepatitis C virus
por: de Almeida, Terezinha M. B., et al.
Publicado: (2010)

Lack of micronuclei formation in bone marrow of rats after oral exposure to thiocyclam insecticide
por: Saleh, Kamel, et al.
Publicado: (2010)

Reduced fertility caused by meiotic defects and micronuclei formation during microsporogenesis in xBrassicoraphanus
por: Shin, Hosub, et al.
Publicado: (2021)

CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI
por: Zhang, Cheng-Zhong, et al.
Publicado: (2015)

Micronuclei as a Predictor for Oral Carcinogenesis
por: Kiran, Kamini, et al.
Publicado: (2018)

Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability
por: Coutelier, Héloïse, et al.
Publicado: (2018)

Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast
por: Sabatinos, Sarah A., et al.
Publicado: (2015)

CHROMOSOME PULVERIZATION IN MICRONUCLEI INDUCED BY TRITIATED THYMIDINE
por: Ikeuchi, Tatsuro, et al.
Publicado: (1972)

Replication of somatic micronuclei in bovine enucleated oocytes
por: Canel, Natalia, et al.
Publicado: (2012)

Chromosomes trapped in micronuclei are liable to segregation errors
por: Soto, Mar, et al.
Publicado: (2018)

Induction of Micronuclei in Cervical Cancer Treated with Radiotherapy
por: Kobayashi, Daijiro, et al.
Publicado: (2020)

The suitability of micronuclei as markers of relative biological effect
por: Heaven, Charlotte J, et al.
Publicado: (2022)

CGAS is a micronucleophagy receptor for the clearance of micronuclei
por: Zhao, Mengmeng, et al.
Publicado: (2021)

Mitotic clustering of pulverized chromosomes from micronuclei
por: Lin, Yu-Fen, et al.
Publicado: (2023)

Epigenetic dysregulation from chromosomal transit in micronuclei
por: Agustinus, Albert S., et al.
Publicado: (2023)

Retinoic Acid-Treated Pluripotent Stem Cells Undergoing Neurogenesis Present Increased Aneuploidy and Micronuclei Formation
por: Sartore, Rafaela C., et al.
Publicado: (2011)

Optimized High-Content Imaging Screening Quantifying Micronuclei Formation in Polymer-Treated HaCaT Keratinocytes
por: Saadati, Fariba, et al.
Publicado: (2022)

PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1
por: Johnson, Catherine, et al.
Publicado: (2016)

Sequestration of Mammalian Rad51-Recombination Protein into Micronuclei
por: Haaf, Thomas, et al.
Publicado: (1999)

Mitotic errors, aneuploidy and micronuclei in Hodgkin lymphoma pathogenesis
por: Krem, Maxwell M., et al.
Publicado: (2013)

Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
por: Luzhna, Lidiya, et al.
Publicado: (2013)

Epigenetic Alterations and an Increased Frequency of Micronuclei in Women with Fibromyalgia
por: Menzies, Victoria, et al.
Publicado: (2013)

Scoring criteria for the evaluation of micronuclei in oral exfoliated cells
por: Grover, Sonal, et al.
Publicado: (2017)

Alerting the immune system to DNA damage: micronuclei as mediators
por: MacDonald, Kate M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e64sd790bintquur19hbke9rlm