Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters

Many diseases arise from mutations, which impair protein folding. The study of folding-deficient variants of G protein-coupled receptors and solute carrier 6 (SLC6) transporters has shed light on the folding trajectory, how it is monitored and how misfolding can be remedied. Reducing the temperature...

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Detalles Bibliográficos
Autores principales: Asjad, H.M. Mazhar, Nasrollahi-Shirazi, Shahrooz, Sucic, Sonja, Freissmuth, Michael, Nanoff, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713384/
https://www.ncbi.nlm.nih.gov/pubmed/29135937
http://dx.doi.org/10.3390/ijms18112416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713384/
https://www.ncbi.nlm.nih.gov/pubmed/29135937
http://dx.doi.org/10.3390/ijms18112416

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