Dysregulated Collagen Homeostasis by Matrix Stiffening and TGF-β1 in Fibroblasts from Idiopathic Pulmonary Fibrosis Patients: Role of FAK/Akt

Idiopathic pulmonary fibrosis (IPF) is an aggressive disease in which normal lung parenchyma is replaced by a stiff dysfunctional scar rich in activated fibroblasts and collagen-I. We examined how the mechanochemical pro-fibrotic microenvironment provided by matrix stiffening and TGF-β1 cooperates i...

Descripción completa

Detalles Bibliográficos
Autores principales: Giménez, Alícia, Duch, Paula, Puig, Marta, Gabasa, Marta, Xaubet, Antoni, Alcaraz, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713399/
https://www.ncbi.nlm.nih.gov/pubmed/29144435
http://dx.doi.org/10.3390/ijms18112431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713399/
https://www.ncbi.nlm.nih.gov/pubmed/29144435
http://dx.doi.org/10.3390/ijms18112431

Ejemplares similares