Computational construction of 3D chromatin ensembles and prediction of functional interactions of alpha-globin locus from 5C data

Conformation capture technologies measure frequencies of interactions between chromatin regions. However, understanding gene-regulation require knowledge of detailed spatial structures of heterogeneous chromatin in cells. Here we describe the nC-SAC (n-Constrained-Self Avoiding Chromatin) method tha...

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Detalles Bibliográficos
Autores principales: Gürsoy, Gamze, Xu, Yun, Kenter, Amy L., Liang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714131/
https://www.ncbi.nlm.nih.gov/pubmed/28981716
http://dx.doi.org/10.1093/nar/gkx784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714131/
https://www.ncbi.nlm.nih.gov/pubmed/28981716
http://dx.doi.org/10.1093/nar/gkx784

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