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Computational construction of 3D chromatin ensembles and prediction of functional interactions of alpha-globin locus from 5C data
Conformation capture technologies measure frequencies of interactions between chromatin regions. However, understanding gene-regulation require knowledge of detailed spatial structures of heterogeneous chromatin in cells. Here we describe the nC-SAC (n-Constrained-Self Avoiding Chromatin) method tha...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714131/ https://www.ncbi.nlm.nih.gov/pubmed/28981716 http://dx.doi.org/10.1093/nar/gkx784 |