Transcriptional accuracy modeling suggests two-step proofreading by RNA polymerase

We suggest a novel two-step proofreading mechanism with two sequential rounds of proofreading selection in mRNA transcription. It is based on the previous experimental observations that the proofreading RNA polymerase cleaves off transcript fragments of at least 2 nt and that transcript elongation a...

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Detalles Bibliográficos
Autores principales: Mellenius, Harriet, Ehrenberg, Måns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714138/
https://www.ncbi.nlm.nih.gov/pubmed/29036494
http://dx.doi.org/10.1093/nar/gkx849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714138/
https://www.ncbi.nlm.nih.gov/pubmed/29036494
http://dx.doi.org/10.1093/nar/gkx849

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