A cell-penetrating antibody inhibits human RAD51 via direct binding

RAD51, a key factor in homology-directed repair (HDR), has long been considered an attractive target for cancer therapy, but few specific inhibitors have been found. A cell-penetrating, anti-DNA, lupus autoantibody, 3E10, was previously shown to inhibit HDR, sensitize tumors to radiation, and mediat...

Descripción completa

Detalles Bibliográficos
Autores principales: Turchick, Audrey, Hegan, Denise C., Jensen, Ryan B., Glazer, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714174/
https://www.ncbi.nlm.nih.gov/pubmed/29036688
http://dx.doi.org/10.1093/nar/gkx871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714174/
https://www.ncbi.nlm.nih.gov/pubmed/29036688
http://dx.doi.org/10.1093/nar/gkx871

Ejemplares similares