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Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production†
In the context of Alzheimer’s disease (AD), the production of HO(•) by copper–amyloid beta (Aβ) in the presence of ascorbate is known to be deleterious for the Aβ peptide itself and also for the surrounding molecules, thus establishing a direct link between AD and oxidative stress. The metal-catalyz...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714184/ https://www.ncbi.nlm.nih.gov/pubmed/27730227 http://dx.doi.org/10.1039/c6mt00150e |