FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs). To repair these lesions, the FA proteins act in a linear hierarchy: following ICL detection on chromatin, the FA core complex monoubiquitinates and recr...

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Detalles Bibliográficos
Autores principales: Thompson, Elizabeth L., Yeo, Jung E., Lee, Eun-A, Kan, Yinan, Raghunandan, Maya, Wiek, Constanze, Hanenberg, Helmut, Schärer, Orlando D., Hendrickson, Eric A., Sobeck, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714191/
https://www.ncbi.nlm.nih.gov/pubmed/29059323
http://dx.doi.org/10.1093/nar/gkx847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714191/
https://www.ncbi.nlm.nih.gov/pubmed/29059323
http://dx.doi.org/10.1093/nar/gkx847

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