C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme–DNA complex and confer high enzyme processivity

Streptomyces topoisomerase I (TopA) exhibits exceptionally high processivity. The enzyme, as other actinobacterial topoisomerases I, differs from its bacterial homologs in its C-terminal domain (CTD). Here, bioinformatics analyses established that the presence of lysine repeats is a characteristic f...

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Detalles Bibliográficos
Autores principales: Strzałka, Agnieszka, Szafran, Marcin J., Strick, Terence, Jakimowicz, Dagmara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714199/
https://www.ncbi.nlm.nih.gov/pubmed/28981718
http://dx.doi.org/10.1093/nar/gkx827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714199/
https://www.ncbi.nlm.nih.gov/pubmed/28981718
http://dx.doi.org/10.1093/nar/gkx827

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