Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B

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The single-stranded DNA cytidine deaminases APOBEC3B, APOBEC3H haplotype I, and APOBEC3A can contribute to cancer through deamination of cytosine to form promutagenic uracil in genomic DNA. The enzymes must access single-stranded DNA during the dynamic processes of DNA replication or transcription,...

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Detalles Bibliográficos
Autores principales: Adolph, Madison B, Love, Robin P, Feng, Yuqing, Chelico, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714209/
https://www.ncbi.nlm.nih.gov/pubmed/28981865
http://dx.doi.org/10.1093/nar/gkx832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714209/
https://www.ncbi.nlm.nih.gov/pubmed/28981865
http://dx.doi.org/10.1093/nar/gkx832

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