Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling

Gain-of-function mutations in the pore-forming subunit of I(Ks) channels, KCNQ1, lead to short QT syndrome (SQTS) and lethal arrhythmias. However, how mutant I(Ks) channels cause SQTS and the possibility of I(Ks)-specific pharmacological treatment remain unclear. V141M KCNQ1 is a SQTS associated mut...

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Detalles Bibliográficos
Autores principales: Lee, Hsiang-Chun, Rudy, Yoram, Liang, Hongwu, Chen, Chih-Chieh, Luo, Ching-Hsing, Sheu, Sheng-Hsiung, Cui, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714284/
https://www.ncbi.nlm.nih.gov/pubmed/29213224
http://dx.doi.org/10.1007/s40846-017-0257-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714284/
https://www.ncbi.nlm.nih.gov/pubmed/29213224
http://dx.doi.org/10.1007/s40846-017-0257-x

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